Sanford, North Carolina Hotel's the Best of Lee County. Visitors to Lee County enjoy exceptional hospitality and amenities when they choose the Holiday Inn Express® Hotel & Suites Sanford, North Carolina. The hotel's experienced staff makes each guest feel at home.When you're traveling for meetings at Bharat Forge, Caterpillar, Pilgrim's Pride or Pfizer, you'll appreciate being just off Hwy-421 and the hotel's location in Sanford, NC. The convenient Business Center services and free high-speed, Wi-Fi access make it easy to stay on top of your deadlines, too. And our meeting room offers an alternative venue for your business meetings in and around Sanford, NC.This hotel is perfect for leisure travelers. Whether you're here to visit the Dennis Wicker Civic Center or interested in the historic Railroad House, we're close to everything. We are an ideal choice when you're here to see a performance at the Temple Theatre or to attend the Southern Side by Side in the Spring. Golfers love spending the day on the stunning local courses, including Tobacco Road Golf Course.What sets us apart from other hotels in Sanford, NC are the extraordinary amenities we offer our guests. From the area's only hotel to win "best hotel" to the friendliest staff ever encountered, we have what you want. The free, hot breakfast, a well-equipped Fitness Center and rooms that are an oasis of comfort are why we're the preferred choice of smart guests. Join us!